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Unreasonable RISK 
by Samuel E. Epstein, M.D.
How to Avoid Cancer from Cosmetics and Personal Care Products: The Neways Story

This book explains how to recognize carcinogens on product labels, boycott such products, and shop for safe alternatives from non-mainstream industries and thus reduce your avoidable risks of cancer.  This is critical as we are losing the winnable war against cancer, which now strikes one in two men and one in three women in their lifetimes

 

D-Glucarate: A Nutrient Against Cancer   by Thomas J. Slaga, Judi Quilici-Timmcke  $3.95  Paperback  48 pages  "A new breakthrough in cancer research: D-Glucarate helps remove toxins and carcinogens from the body" Good Health Guides: Published regularly to give you the newest and best available information on health topics of major importance, written by leading physicians and other health practitioners, researchers, and expert reporters. This is the book that Lyndon Johnson from the Cancer Research Center uses  to introduce physicians to the power of D-Glucarate. He said he has NEVER had a physician turn down learning about D-Glucarate.

D-Toxarate supports the body at a cellular level from environmental factors that you encounter daily - pollution, toxins, and chemicals. The ingredient D-glucarate gives added power to supporting the body in its maintenance of already healthy cholesterol. levels, aiding heart and vascular functions.  Help your cells defend themselves with D-Toxarate.

Key Benefits

• Supplements the body's natural defenses at a cellular level.*

• Supports cellular cleansing and purging of environmental toxins and chemicals.*

• Enhances cardiovascular function.*

• Helps maintain already healthy cholesterol levels.*

• Works with the antioxidant Revenol to support against free radicals.*

Cellular Defense

 

Cellular health is critical to longevity. Cells come under attack from a variety sources -- pollution, tobacco smoke, chemicals seeping from plastics and paints, and toxins released in water, air, and food in the environment.  D-Toxarate provides support as cells defend themselves from this constant assault to promote their health and your longevity.

Key Ingredients

D-glucarate is a natural derivative of fruits and vegetables that permits the natural removal of harmful chemicals and molecules from cells.  Potassium linked d-glucarate also supports maintenance of the kidneys, heart, brain, already healthy cholesterol levels, cardiovascular system, and cellular clenasing.

Ascorbic acid (Vitamin C) is an antixoidant that scavenges heavy metals and free radicals in the body.

Fulvates protect and support cellular health by isolating components that can potentially harm the cellular structure and helping prepare them for excretion.

Don't you deserve the BEST protection?

         

What's Missing
From Multi-Vitamin Supplements?

(From Life Extension, for your information)

In addition to the epidemiological data, researchers have evaluated the molecular effects that fruits and vegetables possess in protecting against cellular damage. These findings provide biologic mechanisms to explain why those who eat a plant-rich diet have such low incidences of chronic disease.

The problem is that few people consistently eat enough fruits and vegetables to protect against aging-related diseases such as stroke, cancer, macular degeneration and heart attack.(1) This is one reason why vitamin supplements are becoming so popular in the United States. The concern about multi-vitamin formulas, however, is that they do not provide all the vital plant components needed to maintain good health.

Over the last 15 years, an enormous amount research data has confirmed the health benefits of disease-preventing plant extracts. Scientists have identified new fruit and vegetable extracts that protect cells against the deleterious effects of aging.

Moving beyond vitamins

Vitamin C, carotenoids and folic acid are examples of plant-based nutrients that can be efficiently consumed in the form of dietary supplements. Researchers are now moving beyond traditional nutrients in their quest to discover additional ways of protecting against disease. One botanical extract that offers tremendous potential is called D-glucarate. This extract appears to protect against cancer and other diseases via different mechanisms than antioxidants.

D-glucarate is found in grapefruit, apples, oranges, broccoli and brussel sprouts.(2-3) Consumption of these types of fruits and vegetables confers a protective effect against cancer, and D-glucarate is a component of these foods that has scientists very excited.

The body is bombarded with carcinogens on a daily basis. These cancer-causing agents include pesticides, over-cooked food, alcohol, food additives, tobacco, fungal mutagens and industrial pollutants. While avoiding carcinogens is difficult, it may be possible to mitigate their lethal effects by providing the body with phyto-nutrients (plant extracts) that facilitate the detoxification and removal of these dangerous substances from the body.

D-glucarate is one of these phyto-nutrients that protects against cancer-causing agents in a way that is separate and apart from the beneficial effects of antioxidants (vitamins C, E, cysteine, etc,) and methylation-enhancing agents (folic acid, vitamin B12 and TMG). D-glucarate works by supporting detoxification and removal of dangerous chemicals, and also by protecting against the mutating effects that these carcinogens induce on cellular DNA.(3)

There are several mechanisms by which the body detoxifies itself. One way of protecting against toxic overload involves the use of antioxidants to inhibit the damaging effects of free radicals. Uncontrolled free radical reactions have been identified as causative or contributing factors in most human disease states. The consumption of antioxidants (vitamin E, n-acetyl-cysteine, selenium, carotenoids, etc.) are essential to protect against toxic free radical reactions. Neutralizing free radicals, however, is only one part of the detoxification process. There are additional pathways the body must use if it is to sufficiently rid itself of DNA-damaging toxins that can cause cancer and other diseases.

Another pathway of detoxification occurs when toxins or carcinogens are combined with water soluble substances, thus making them more easily removed from the body. This process is called glucuronidation. The phyto-extract D-glucarate has been shown to support this important detoxification mechanism. The following known carcinogens are removed from the body by the glucuronidation process:

Note: To give you some idea about how 
dangerous heterocylic amines are, 
click HERE to read more. 
(A new window will open, close to return).

How does D-Glucarate work?

As just discussed, glucuronidation is a process by which the body naturally detoxifies itself.    As people grow older and become overly exposed to toxins, a dangerous enzyme forms in the body called beta-glucuronidase. When levels of beta-glucuronidase become too high, it reverses the glucuronidation process and releases the toxins or carcinogens back into the bloodstream. This means that harmful compounds that would normally bind to inert molecules to be removed from the body are permitted to go free and damage cells.

At the University of Texas M.D. Anderson Cancer Center, repeated in vitro and animal studies have demonstrated the effectiveness of D-glucarate. Oral ingestion of D-glucarate has been positively shown to inhibit the dangerous beta-glucuronidase enzyme. This means the body is better able to get rid of carcinogens and toxic waste products. In one animal study, a single dose of D-glucarate was able to suppress beta-glucuronidase activity by 57% in the blood, 44% in the liver, 39% in the intestines and 37% in the lungs.(3)

In a rat study, the administration of D-glucarate for five months inhibited the initiation stage of liver cancer after the rats had been intentionally exposed to a known carcinogen. Researchers concluded that D-glucarate has a direct effect in preventing liver cancer that was attempted to be induced by the carcinogen, diethylnitrosamine.(4)

Research studies have shown that D-glucarate inhibits mammary tumor incidence.(7-10) One study in rats who already had breast cancer showed that oral D-glucurate administration resulted in a 50% inhibition of beta-glucuronidase resulting in a 30% reduction in mammary tumor growth during the promotion stage and a four-fold reduction in the absolute number of tumors.(11)

In a study conducted in Europe, rats fed D-glucarate and a vitamin A analog drug demonstrated a 20% reduction in mammary tumor volume.(12) Another study showed a more than 70% decrease in mammary tumor development in rats exposed to carcinogens who were also administered D-glucarate.(13) Still another study looked at the effects of D-glucarate on the initiation and promotional stages of mammary cancer. The results showed a reduction of 28% during the initiation stage, while cell replication was reduced by 42% during the promotion stage.(14) Inhibition at the initiation stage is a very important part of D-glucarate’s actions since it lessens the risk that cancer will even start.

D-glucarate is being used in a Phase I human trial at Memorial Sloan-Kettering Cancer Center in women at high risk for developing breast cancer. This study is in collaboration with the National Cancer Institute and National Institutes of Health.

When mice were exposed to known carcinogens found in tobacco smoke, D-glucarate was shown to inhibit lung cancer development.(6,15) On a molecular basis, D-glucarate was shown to cause a 70% decrease in the binding of the carcinogen benzopyrene to DNA in both mouse livers and lungs.(6) Since benzopyrene is a potent carcinogen found in cigarette smoke, D-glucarate could be of particular benefit to smokers and those exposed to environmental airborne carcinogens.(6,16)

When a carcinogen known to induce intestinal cancer was given to rats, D-glucarate was shown to inhibit adenocarcinoma formation when given at the initiation stage. When administered after tumor development, D-glucarate significantly inhibited the size and metastatic potential of intestinal and colon cancers.(17) The researchers made comments suggesting that D-glucarate may be effective in the prevention and treatment of cancer by inhibiting the beta-glucuronidase enzyme and by inhibiting cancer cell proliferation induced by chemical carcinogens.

One study indicates a potential for D-glucurate to prevent bladder cancer, while two studies indicate D-glucarate may have a protective effect against skin cancer.(18-21,145,146) A preliminary study showed that orally administered D-glucarate inhibited the growth of transplanted rat prostate tumors and reduced the levels of a tumor marker for prostate cancer.(21,147)

The results of various animal studies on D-glucarate indicates that this plant extract may be effective in inhibiting cancer during the initiation, promotion and progression phases. Human studies are just now beginning to determine if the results seen in animals will also be found in people. Since D-glucarate has no known side effects when ingested in moderate doses, and is a component of fruits and vegetables that have demonstrated a powerful cancer preventative benefits, it would appear appropriate to add this plant-constituent as part of an overall program designed to lower the risk of the following cancers:

References

1. Li R, et al. Trends in fruit and vegetable consumption among adults in 16 US states: Behavioral Risk Factor Surveillance System, 1990-1996. Am J Public Health 2000 May;90(5):777-81.

 

2. Walaszek Z, et al. D-glucaric acid content of various fruits and vegetables and cholesterol-lowering effects of dietary D-glucarate in the rat. Nutrition Research (United States) 1996, 16/4 (673-681).

 

3. Dwivedi C, et al. Effect of calcium glucarate on beta-glucoronidase activity and glucarate content of certain vegetable and fruits. Biochemical Medicine and Metabolic Biology (United States) 1990, 43/2 (83-92).

 

4. Oredipe OA, et al. Dietary glucarate-mediated inhibition of initiation of diethylnitrosamine-induced hepatocarcinogenesis. Toxicology; 74 (2-3). 1992. 209-222.

 

5. Cohen LA, et al. Wheat bran and psyllium diets: effects on N-methylnitrosourea-induced mammary tumorigenesis in F344 rats. J Natl Cancer Inst 1996 Jul 3;88(13):899-907.

 

6. Walaszek Z, et al. Dietary glucarate-mediated reduction of sensitivity of murine strains to chemical carcinogenesis. Cancer Lett 1986 Oct;33(1):25-32.

 

7. Walaszek Z, et al. Antiproliferative effect of dietary glucarate on the Sprague-Dawley rat mammary gland. Cancer Lett 1990 Jan;49(1):51-7.

 

8. Heerdt A.S, et al. Calcium glucarate as a chemopreventive agent in breast cancer. Israel Journal of Medical Sciences (Israel) 1995, 31/2-3 (101-105).

 

9. Bhatnagar R, et al. Growth suppression of human breast carcinoma cells in culture by N-(4-hydroxyphenyl)retinamide and its glucuronide and through synergism with glucarate. Biochemical Pharmacology (United Kingdom) 1991, 41/10 (1471-1477).

 

10. Curley Jr. R.W, et al. Activity of D-glucarate analogues: Synergistic antiproliferative effects with retinoid in cultured human mammary tumor cells appear to specifically require the D-glucarate structure. Life Sciences 1994, 54/18 (1299-1303).

 

11. Slaga,T. J. 1999. D-Glucarate a Nutrient Against Cancer. Keats Publishing – Lincolnwood, Chicago Illinois. page 33.

 

12. Abou-Issa H, et al. Antitumour synergism between non-toxic dietary combinations of isotretinoin and glucarate. European Journal of Cancer Part A: General Topics (United Kingdom) 1992, 28/4-5 (784-788).

 

13. Walaszek Z, et al. Dietary glucarate as anti-promoter of 7,12- dimethylbenz[a]anthracene-induced mammary tumorigenesis. Carcinogenesis 1986 Sep;7(9):1463-6.

 

14. Abou-Issa H, et al. Relative efficacy of glucarate on the initiation and promotion phases of rat mammary carcinogenesis. Anticancer Res 1995 May-Jun; 15(3):805-10.

 

15. Oredipe O.A, et al. Chemopreventative activity of dietary glucarate on azoxymethane-induced altered hepatic foci in rats. Research Communications in Chemical Pathology and Pharmacology 1989, 65/3 (345-359).

 

16. Walaszek Z. Potential use of D-glucaric acid derivatives in cancer prevention. Cancer Lett 1990 Oct 8;54(1-2):1-8.

 

17. Dwivedi C, et al. Effects of the experimental chemopreventative agent, glucarate, on intestinal carcinogenesis in rats. Carcinogenesis 1989 Aug; 10(8):1539-41.

 

18. Dutton, G.J. 1980. Glucuronidation of Drugs and other Compounds. Boca Raton, FL.: CRC Press.

 

19. Walaszek Z. Potential use of D-glucaric acid derivatives in cancer prevention. Cancer Letters (Ireland) 1990, 54/1-2 (1-8).

 

20. Boone C.W, et al. Screening for chemopreventive (anticarcinogenic) compounds in rodents. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis (Netherlands) 1992, 267/2 (251-255).

 

21. Walaszek Z. Chemopreventive properties of D-glucaric acid derivatives. Cancer Bulletin (United States) 1993, 45/5 (453-457).

 

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COMPLEMENTARY PRODUCTS

• Maximol Solutions - Advanced mineral nutritional support complex.  A nutrient rich solution composed of minerals, vitamins, amino acids, enzymes, and other significant nutrients.

• Lemon Essential Oil - May assist in stimulating the immune system

• Orange Essential Oil - Bolsters the immune system, Orange supports the nervous, digestive and respiratory systems

• Lavender Essential Oil - May assist in the body's defense against epidermal infections

• Grapefruit Essential Oil - Enhances the circulatory, glandular, urinary and nervous systems

• VMM - Exerts its primary effects on the internal immune system and associated organs

• Echinacea - Supports the ability of white blood cells to surround and destroy bacterial and viral infection in the blood.

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